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Aminophenol-modified gold nanoparticles kill bacteria with minimal ototoxicity.

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We report aminophenol (A)-modified gold nanoparticles (AGNPs), which have potent antibacterial effects against multidrug-resistant bacteria with a broad antibacterial spectrum. Moreover, a series of in vitro and in vivo models… Click to show full abstract

We report aminophenol (A)-modified gold nanoparticles (AGNPs), which have potent antibacterial effects against multidrug-resistant bacteria with a broad antibacterial spectrum. Moreover, a series of in vitro and in vivo models indicate that AGNPs are much less ototoxic than aminoglycosides. AGNPs thus have the potential to replace aminoglycosides as novel antibacterial agents for clinical applications.

Keywords: modified gold; bacteria minimal; gold nanoparticles; aminophenol modified; nanoparticles kill; kill bacteria

Journal Title: Chemical communications
Year Published: 2022

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