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A fluorogenic RNA aptamer nanodevice for the low background imaging of mRNA in living cells.

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A fluorogenic RNA aptamer nanodevice integrating an entropy-driven RNA amplifier with near-infrared (NIR) light control was developed, affording high contrast and sensitivity for imaging low-abundance mRNA in living cells. The… Click to show full abstract

A fluorogenic RNA aptamer nanodevice integrating an entropy-driven RNA amplifier with near-infrared (NIR) light control was developed, affording high contrast and sensitivity for imaging low-abundance mRNA in living cells. The design principle offers a new approach for developing low-background imaging systems for live-cell studies and manipulation.

Keywords: aptamer nanodevice; rna aptamer; low background; living cells; mrna living; fluorogenic rna

Journal Title: Chemical communications
Year Published: 2022

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