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Hydrogen peroxide (H2O2), a key reactive oxygen species (ROS), is mainly produced endogenously in the mitochondria. The selective monitoring of H2O2 in living cells is of great significance for understanding… Click to show full abstract
Hydrogen peroxide (H2O2), a key reactive oxygen species (ROS), is mainly produced endogenously in the mitochondria. The selective monitoring of H2O2 in living cells is of great significance for understanding the diagnosis and pathogenesis of cancers, Alzheimer's disease and diabetes. Here, we constructed a versatile AIE probe, TTPy-H2O2, which exhibited excellent performance in the specific visualization of H2O2 in various living cells with mitochondria targeting, excellent biocompatibility, photostability, and remarkable ROS generation ability. Red/near-infrared fluorescence first located in the mitochondria could light up lipid droplets with bright yellow fluorescence after responding to H2O2, which can realize both imaging and photodynamic therapy (PDT) for cancer therapy.
Journal Title: Materials Chemistry Frontiers
Year Published: 2021
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