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A novel spiro-pyrrolidine (SPD)-derived bifunctional thiourea catalyst has been developed, enabling the development of a stereoselective conjugate addition of furfurals to β,γ-unsaturated α-ketoesters. The reaction represents an example of asymmetric… Click to show full abstract
A novel spiro-pyrrolidine (SPD)-derived bifunctional thiourea catalyst has been developed, enabling the development of a stereoselective conjugate addition of furfurals to β,γ-unsaturated α-ketoesters. The reaction represents an example of asymmetric trienamine catalysis in the benzylic C–H functionalization of 5-benzylfurfurals, and the rigid spirocyclic framework of the catalyst is proven to be essential for a highly enantioselective transformation.
Keywords:
catalyst;
conjugate addition;
thiourea catalyst;
spiro pyrrolidine
Journal Title: Organic chemistry frontiers
Year Published: 2021
Link to full text (if available)
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Journal Title: Organic chemistry frontiers
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!