Photo by vaccinium from unsplash
A novel radical cross-coupling/cyclization of 2-(pyridin-2-yl)acetate derivatives and sulfoxonium ylides is developed, which provides a straightforward access to structurally diverse methylthio-substituted indolizine. A series of 1,2,3-trisubstituted indolizines are readily synthesized… Click to show full abstract
A novel radical cross-coupling/cyclization of 2-(pyridin-2-yl)acetate derivatives and sulfoxonium ylides is developed, which provides a straightforward access to structurally diverse methylthio-substituted indolizine. A series of 1,2,3-trisubstituted indolizines are readily synthesized in modest yields. In this process, sulfoxonium ylides undergo disproportionation and produce a type of indolizine derivative which has not been seen before. This route reveals a novel discovery that DMSO does not drop off from sulfoxonium ylides.
Journal Title: Organic chemistry frontiers
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!