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Palladium-catalyzed carbonylative synthesis of 5-trifluoromethyl-1,2,4-triazoles from trifluoroacetimidohydrazides and aryl iodides

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A new palladium-catalyzed three-component carbonylative procedure for the construction of 5-trifluoromethyl-1,2,4-triazoles from trifluoroacetimidohydrazides and aryl iodides has been developed. TFBen is applied as a safe and convenient solid CO surrogate… Click to show full abstract

A new palladium-catalyzed three-component carbonylative procedure for the construction of 5-trifluoromethyl-1,2,4-triazoles from trifluoroacetimidohydrazides and aryl iodides has been developed. TFBen is applied as a safe and convenient solid CO surrogate here.

Keywords: triazoles trifluoroacetimidohydrazides; trifluoromethyl triazoles; aryl iodides; palladium catalyzed; trifluoroacetimidohydrazides aryl

Journal Title: Organic Chemistry Frontiers
Year Published: 2021

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