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A single-molecular ruthenium(II) complex-based NIR-II fluorophore for enhanced chemo-photothermal therapy.

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Novel NIR-II Ru(II) polypyridyl fluorophore Ru-1 dots for synergistic chemo-photothermal therapy against 4T1 tumors were designed and synthesized. Guided by in vivo NIR-II fluorescence imaging, the synergistic therapeutic efficacy, intracellular… Click to show full abstract

Novel NIR-II Ru(II) polypyridyl fluorophore Ru-1 dots for synergistic chemo-photothermal therapy against 4T1 tumors were designed and synthesized. Guided by in vivo NIR-II fluorescence imaging, the synergistic therapeutic efficacy, intracellular delivery, and biodistribution of the Ru-1 dots were precisely tracked in real-time.

Keywords: single molecular; chemo photothermal; molecular ruthenium; photothermal therapy

Journal Title: Chemical communications
Year Published: 2022

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