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Carrier-free nanomedicine for enhanced photodynamic tumor therapy through glutathione S-transferase inhibition.

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Antioxidant-defense systems of tumor cells protect them from oxidative damage. Herein, a carrier-free nanomedicine is developed based on chlorine e6 (Ce6) and coniferyl ferulate (Con), which inhibits glutathione S-transferase (GST)… Click to show full abstract

Antioxidant-defense systems of tumor cells protect them from oxidative damage. Herein, a carrier-free nanomedicine is developed based on chlorine e6 (Ce6) and coniferyl ferulate (Con), which inhibits glutathione S-transferase (GST) activity to hamper antioxidant systems and amplify intracellular oxidative stress for enhanced photodynamic therapy.

Keywords: glutathione transferase; enhanced photodynamic; free nanomedicine; carrier free; tumor

Journal Title: Chemical communications
Year Published: 2022

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