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Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro.

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A series of specific and potent fluorescent ligands were developed for labelling and visualizing Kv7.2/7.3 based molecular rotation restriction. Probes 21b and 24a were found to be safe and convenient… Click to show full abstract

A series of specific and potent fluorescent ligands were developed for labelling and visualizing Kv7.2/7.3 based molecular rotation restriction. Probes 21b and 24a were found to be safe and convenient tools to detect and visualize Kv7.2/7.3 in live cells and mouse brain tissue.

Keywords: design development; fluorescent ligands; development selective; ligands detection; competitive fluorescent; selective competitive

Journal Title: Chemical communications
Year Published: 2022

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