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Sustained-release nanocapsule based on a 3D COF for long-term enzyme prodrug therapy of cancer.

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A well-designed three-dimensional (3D) covalent organic framework (COF) was constructed as a nanocapsule for the encapsulation of horseradish peroxidase (HRP), which could realize sustained release of HRP to prolong the… Click to show full abstract

A well-designed three-dimensional (3D) covalent organic framework (COF) was constructed as a nanocapsule for the encapsulation of horseradish peroxidase (HRP), which could realize sustained release of HRP to prolong the duration of the therapeutic agents and promote long-term enzyme prodrug therapy.

Keywords: cof; term enzyme; prodrug therapy; long term; sustained release; enzyme prodrug

Journal Title: Chemical communications
Year Published: 2022

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