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Copper-catalyzed C2 alkenylation of pyridine-N-oxides with alkynes.

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A general and expedient method to construct the scaffolds of 2-alkenylpyridines, through copper-catalyzed C2 alkenylation of pyridine-N-oxides with alkynes, has been disclosed. This protocol shows operational simplicity, good functional group… Click to show full abstract

A general and expedient method to construct the scaffolds of 2-alkenylpyridines, through copper-catalyzed C2 alkenylation of pyridine-N-oxides with alkynes, has been disclosed. This protocol shows operational simplicity, good functional group compatibility and broad substrate scope.

Keywords: alkenylation pyridine; catalyzed alkenylation; oxides alkynes; copper catalyzed; pyridine oxides

Journal Title: Chemical communications
Year Published: 2022

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