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Atomic insight into short helical peptide comprised of consecutive multiple aromatic residues.

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The occurrence of sequential multiple aromatic residues in a helical sequence is rare compared to the β-sheet rich structure. Here, using helix promoting α-aminoisobutyric acid (Aib) residues, we unravel atomistic… Click to show full abstract

The occurrence of sequential multiple aromatic residues in a helical sequence is rare compared to the β-sheet rich structure. Here, using helix promoting α-aminoisobutyric acid (Aib) residues, we unravel atomistic details of the helical secondary structure formation and the super helical assembly of two heptapeptides composed of sequential five and six phenylalanine (Phe) residues.

Keywords: aromatic residues; insight short; multiple aromatic; atomic insight; short helical; helical peptide

Journal Title: Chemical communications
Year Published: 2022

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