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Practical method for hydroxyl-group protection using strontium metal and readily available silyl chlorides.

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We have found that the etherification of silyl-protected secondary alcohols proceeds smoothly in the presence of strontium metal using silyl chloride instead of the expensive, yet more reactive, and commonly… Click to show full abstract

We have found that the etherification of silyl-protected secondary alcohols proceeds smoothly in the presence of strontium metal using silyl chloride instead of the expensive, yet more reactive, and commonly used silyl triflate. The reaction occurred almost completely with various alcohols.

Keywords: method hydroxyl; practical method; strontium metal; silyl

Journal Title: Chemical communications
Year Published: 2022

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