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A novel fluorogenic probe for facile and efficient detection of a target protein that binds to a bioactive small molecule was developed. The probe was composed of a thiol-activated fluorogenic… Click to show full abstract
A novel fluorogenic probe for facile and efficient detection of a target protein that binds to a bioactive small molecule was developed. The probe was composed of a thiol-activated fluorogenic moiety bearing an alkyne tag and a protein binding ligand linked to a photoreactive protein labeling group. The new probe in conjunction with affinity chromatography and mass spectrometry was utilized to identify a target protein in cell lysates.
Keywords:
fluorogenic probe;
detection target;
protein;
target protein;
probe
Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!