An enantioselective synthesis of polycyclic fluorinated pyrrolidines has been achieved by Cu-catalyzed intramolecular 1,3-dipolar cycloaddition of azomethine ylides with fluorinated dipolarophiles. The method displays a wide scope and afforded the… Click to show full abstract
An enantioselective synthesis of polycyclic fluorinated pyrrolidines has been achieved by Cu-catalyzed intramolecular 1,3-dipolar cycloaddition of azomethine ylides with fluorinated dipolarophiles. The method displays a wide scope and afforded the desired cycloadducts in high yields with up to 99% ee. These results demonstrate that fluoroalkyl substituents are excellent activating groups in this transformation.
Keywords:
dipolar cycloaddition;
intramolecular dipolar;
cycloaddition azomethine;
ylides fluorinated;
fluorinated dipolarophiles;
azomethine ylides
Journal Title: Chemical communications
Year Published: 2022
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Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
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recommendations!