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Expedient Ni(OTf)2/visible light photoredox-catalyzed annulation of donor-acceptor cyclopropanes with cyclic secondary amines.

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The annulative coupling of donor-acceptor cyclopropanes with cyclic secondary amines is reported using the combination of Ni(OTf)2 and visible light assisted eosin Y catalysis for tandem C-N and C-C bond… Click to show full abstract

The annulative coupling of donor-acceptor cyclopropanes with cyclic secondary amines is reported using the combination of Ni(OTf)2 and visible light assisted eosin Y catalysis for tandem C-N and C-C bond formation. The reaction sequence provides a potential synthetic tool for the construction of pyrrolotetrahydroisoquinolines.

Keywords: acceptor cyclopropanes; secondary amines; donor acceptor; cyclopropanes cyclic; otf visible; cyclic secondary

Journal Title: Chemical communications
Year Published: 2022

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