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An iron-catalyzed decarboxylative C-N coupling of α-amino acids with dioxazolones is described herein to synthesize amide derivatives under visible-light. The desired products can be given in good to excellent yields… Click to show full abstract
An iron-catalyzed decarboxylative C-N coupling of α-amino acids with dioxazolones is described herein to synthesize amide derivatives under visible-light. The desired products can be given in good to excellent yields under simple, mild, and oxidant-free conditions. This protocol provides a practical route for the transformation of α-amino acids to the corresponding amides. Computational studies were carried out to shed light on the mechanism of this reaction.
Keywords:
amino acids;
coupling amino;
acids dioxazolones;
decarboxylative coupling;
iron catalyzed;
amino
Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!