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Enantioselective C-H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis.

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An enantioselective ortho-C(sp2)-H functionalization of ketones with 1,6-enynes is demonstrated via photoredox/cobalt dual catalysis. The method exhibits high yields, functional group tolerance, and selectivity. Mechanistic studies suggested the operation of… Click to show full abstract

An enantioselective ortho-C(sp2)-H functionalization of ketones with 1,6-enynes is demonstrated via photoredox/cobalt dual catalysis. The method exhibits high yields, functional group tolerance, and selectivity. Mechanistic studies suggested the operation of visible-light mediated low-valent cobalt complex generation, intramolecular cyclization, ortho-C-H bond insertion, and reductive elimination as the key mechanistic steps.

Keywords: cobalt; via photoredox; ketones enynes; dual catalysis; cobalt dual; photoredox cobalt

Journal Title: Chemical communications
Year Published: 2022

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