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An enantioselective ortho-C(sp2)-H functionalization of ketones with 1,6-enynes is demonstrated via photoredox/cobalt dual catalysis. The method exhibits high yields, functional group tolerance, and selectivity. Mechanistic studies suggested the operation of… Click to show full abstract
An enantioselective ortho-C(sp2)-H functionalization of ketones with 1,6-enynes is demonstrated via photoredox/cobalt dual catalysis. The method exhibits high yields, functional group tolerance, and selectivity. Mechanistic studies suggested the operation of visible-light mediated low-valent cobalt complex generation, intramolecular cyclization, ortho-C-H bond insertion, and reductive elimination as the key mechanistic steps.
Keywords:
cobalt;
via photoredox;
ketones enynes;
dual catalysis;
cobalt dual;
photoredox cobalt
Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!