Bacteria-mediated reactions can utilize the natural activities of bacteria to produce bioactive products. Here, bacteria-mediated polymerization of the acrylamide-functionalized peptide Trp-Arg-Lys (Am-WRK) afforded an antibacterial polymer, PAm-WRK, which simulates the… Click to show full abstract
Bacteria-mediated reactions can utilize the natural activities of bacteria to produce bioactive products. Here, bacteria-mediated polymerization of the acrylamide-functionalized peptide Trp-Arg-Lys (Am-WRK) afforded an antibacterial polymer, PAm-WRK, which simulates the cationic and hydrophobic structures of antimicrobial peptides. Facultative anaerobes with strong reductive abilities exhibited better reactivity and achieved selective antibacterial effects through non-covalent interactions with bacterial membranes. This bacteria-mediated synthesis of AMP-mimic polymers provides a new strategy for overcoming bacterial resistance and for the in situ generation of bioactive functional materials.
Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!