The NHC-catalyzed asymmetric [3+2] cyclization of benzoyl cyanides to homoenolate generated in situ from enals was reported. This methodology leads to the efficient construction of a series of chiral cyclic… Click to show full abstract
The NHC-catalyzed asymmetric [3+2] cyclization of benzoyl cyanides to homoenolate generated in situ from enals was reported. This methodology leads to the efficient construction of a series of chiral cyclic compounds bearing vicinal quaternary stereocenters under mild reaction conditions. Additionally, the representative large-scale and derivatization reactions of the chiral cyclic products reveal the potential synthetic utility of this protocol.
Keywords:
catalyzed cyclization;
disubstituted enals;
nhc catalyzed;
benzoyl cyanides;
cyclization disubstituted
Journal Title: Chemical communications
Year Published: 2022
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Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
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recommendations!