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Iridium-catalyzed asymmetric C-H addition of an N-methyl group on 3-trifluoromethyl-2-(N-methylamino)pyridine to cyclic alkenes was realized by using a phosphine-olefin ligand. Indene and its 7-substituted derivatives, acenaphthylene, and some bicyclic alkenes… Click to show full abstract
Iridium-catalyzed asymmetric C-H addition of an N-methyl group on 3-trifluoromethyl-2-(N-methylamino)pyridine to cyclic alkenes was realized by using a phosphine-olefin ligand. Indene and its 7-substituted derivatives, acenaphthylene, and some bicyclic alkenes underwent the addition to give the corresponding products in good yields with high enantioselectivity.
Keywords:
phosphine olefin;
addition;
asymmetric addition;
addition methyl;
cyclic alkenes
Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!