Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we… Click to show full abstract
Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [18F]BiPET-2, and its in vitro and preclinical evaluation in glioblastoma models.
Keywords:
targeted probe;
bromodomain extraterminal;
enables tumour;
probe enables;
extraterminal protein;
protein targeted
Journal Title: Chemical communications
Year Published: 2023
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Journal Title: Chemical communications
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!