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Regioselective O-alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion.

Selective alkylation of 2-pyridone could solve a challenge in chemistry and streamline the synthesis of important molecules. Here we report the regioselective O-alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion. In… Click to show full abstract

Selective alkylation of 2-pyridone could solve a challenge in chemistry and streamline the synthesis of important molecules. Here we report the regioselective O-alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion. In the catalytic system, alkylation of 2-pyridone was achieved with unprecedented regioselectiviy (>99 : 1). This protocol is characterized by mild reaction conditions, metal-free, and simplicity. Moreover, this method provides the desired products in good yield and demonstrates a broad substrate scope in this transformation.

Keywords: catalyzed carbenoid; tfoh catalyzed; alkylation pyridones; alkylation; pyridones tfoh; regioselective alkylation

Journal Title: Chemical communications
Year Published: 2022

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