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Tracking endoplasmic reticulum viscosity during ferroptosis and autophagy using a molecular rotor probe.

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Ferroptosis is a unique non-apoptotic cell death process associated with endoplasmic reticulum (ER) stress-related diseases. We have designed and synthesized a far-red emitting and ER targetable viscosity-sensitive fluorophore to track… Click to show full abstract

Ferroptosis is a unique non-apoptotic cell death process associated with endoplasmic reticulum (ER) stress-related diseases. We have designed and synthesized a far-red emitting and ER targetable viscosity-sensitive fluorophore to track ER-phagy. Furthermore, the ER viscosity alteration during the ferroptosis process was investigated via intensity and lifetime-based spectroscopy and microscopy.

Keywords: endoplasmic reticulum; ferroptosis; tracking endoplasmic; reticulum viscosity

Journal Title: Chemical communications
Year Published: 2023

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