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Disclosed herein is an efficient organocatalytic formal N-H insertion reaction of arylamines with α-keto sulfoxonium ylides bearing two aryl groups, delivering a broad range of α-tertiary aminoketones with good to… Click to show full abstract
Disclosed herein is an efficient organocatalytic formal N-H insertion reaction of arylamines with α-keto sulfoxonium ylides bearing two aryl groups, delivering a broad range of α-tertiary aminoketones with good to excellent yields and enantioselectivities (up to 90% yield and 94% ee). The utilities of this protocol were also demonstrated by facile preparation of enantioenriched 2-amino-1,2-diarylethanol bearing two different aryl groups, a type of important building block lacking efficient access.
Keywords:
tertiary aminoketones;
two aryl;
bearing two;
aryl groups;
sulfoxonium ylides;
ylides bearing
Journal Title: Chemical communications
Year Published: 2023
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!