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Electrochemical cycloaddition of hydrazones with cyanamide for the synthesis of substituted 5-amine-1,2,4-triazoles.

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An eco-friendly and efficient electrochemical method for the synthesis of 5-amine-1,2,4-triazole derivatives has been developed by employing hydrazones or in situ generation of hydrazones with cyanamide using KI as the… Click to show full abstract

An eco-friendly and efficient electrochemical method for the synthesis of 5-amine-1,2,4-triazole derivatives has been developed by employing hydrazones or in situ generation of hydrazones with cyanamide using KI as the catalyst and electrolyte. This strategy could be smoothly conducted with simple reaction conditions at room temperature without the addition of a chemical oxidant in an undivided cell, and cyanamide has been proven to be of great value in electrosynthesis.

Keywords: cycloaddition hydrazones; synthesis substituted; electrochemical cycloaddition; synthesis; hydrazones cyanamide; cyanamide synthesis

Journal Title: Chemical communications
Year Published: 2023

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