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Masking thiol reactivity with thioamide, thiourea, and thiocarbamate-based MBPs.

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Thioamides, thioureas, and thiocarbamates are introduced as stable, sulfur-based metal-binding pharmacophores (MBPs) for use in metalloenzyme fragment-based drug discovery (mFBDD). MBP reactivity, bioactivity, and structural studies show that these molecules… Click to show full abstract

Thioamides, thioureas, and thiocarbamates are introduced as stable, sulfur-based metal-binding pharmacophores (MBPs) for use in metalloenzyme fragment-based drug discovery (mFBDD). MBP reactivity, bioactivity, and structural studies show that these molecules can act as ligands for Zn(II)-dependent metalloenzymes including human carbonic anhydrase II (hCAII) and matrix metalloproteinase-2 (MMP-2).

Keywords: thiourea thiocarbamate; thiol reactivity; thioamide thiourea; masking thiol; reactivity; reactivity thioamide

Journal Title: Chemical communications
Year Published: 2023

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