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The δ conformation is a local secondary structure in proteins that implicates a πamide N-H⋯N interaction between a backbone N atom and the NH of the following residue. Small-molecule models… Click to show full abstract
The δ conformation is a local secondary structure in proteins that implicates a πamide N-H⋯N interaction between a backbone N atom and the NH of the following residue. Small-molecule models thereof have been limited so far to rigid proline-type compounds. We show here that in derivatives of a cyclic amino acid with a sulphur atom in the γ-position, specific side-chain/backbone N-H⋯S interactions stabilize the δ conformation sufficiently to allow it to compete with classical C5 and C7 H-bonded conformers.
Keywords:
interactions reveal;
conformation;
chain;
reveal protein;
non covalent;
covalent interactions
Journal Title: Chemical communications
Year Published: 2023
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!