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tBuOK/DMSO/O2 Catalyzed direct α-C(sp3)-H Alkylation with Styrenes: productive α-amino radical for hydroaminoalkylation

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Direct α-C(sp3)-H alkylation of hydroaminoalkylation (HAA) catalyzed by tBuOK/DMSO/O2 from α-aryl benzylamines with styrenes is reported. The reaction has delivered diverse selectively substituted amines and N-heterocycles under mild conditions, showing... Click to show full abstract

Direct α-C(sp3)-H alkylation of hydroaminoalkylation (HAA) catalyzed by tBuOK/DMSO/O2 from α-aryl benzylamines with styrenes is reported. The reaction has delivered diverse selectively substituted amines and N-heterocycles under mild conditions, showing...

Keywords: sp3 alkylation; direct sp3; hydroaminoalkylation; tbuok dmso

Journal Title: Organic Chemistry Frontiers
Year Published: 2023

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