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Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange

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Our experiments indicate hyperpolarized proton signals in the entire structure of remdesivir are obtained due to a long-distance polarization transfer by para-hydrogen. SABRE-based biological real-time reaction monitoring, by using a… Click to show full abstract

Our experiments indicate hyperpolarized proton signals in the entire structure of remdesivir are obtained due to a long-distance polarization transfer by para-hydrogen. SABRE-based biological real-time reaction monitoring, by using a protein enzyme under mild conditions is carried out. It represents the first successful para-hydrogen based hyperpolarization application in biological reaction monitoring.

Keywords: biological reaction; reaction; reaction monitoring; hyperpolarization study

Journal Title: RSC Advances
Year Published: 2022

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