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NMR analysis of the enantiomeric purity of chiral diols by a new chiral boron agent

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A new boric agent with bridged structure, boric acid D, was first synthesized and used as an excellent chiral derivative agent for highly efficient enantiodiscrimination of various diols. The derivatization… Click to show full abstract

A new boric agent with bridged structure, boric acid D, was first synthesized and used as an excellent chiral derivative agent for highly efficient enantiodiscrimination of various diols. The derivatization reaction is fast and complete, easy to operate and has high accuracy in measurement of ee values. The characteristic split NMR signals are well-distinguishable with a large chemical shift nonequivalence (up to 0.39 ppm).

Keywords: enantiomeric purity; nmr analysis; chiral diols; agent; analysis enantiomeric; purity chiral

Journal Title: RSC Advances
Year Published: 2022

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