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A domino condensation–cyclization method is developed to synthesize indolizidine alkaloids using a P4O10/TfOH reagent system without the employment of either a catalyst or solvent. The use of a few aliphatic… Click to show full abstract
A domino condensation–cyclization method is developed to synthesize indolizidine alkaloids using a P4O10/TfOH reagent system without the employment of either a catalyst or solvent. The use of a few aliphatic and aromatic dicarboxylic acids is shown along with various primary amines. This method is suitable for synthesizing pyrrolo[2,1-a]isoquinolines, pyrido[2,1-a]isoquinolines, and isoindolo[1,2-a]isoquinolinones in excellent yields. When phthalic acid is used, a workup with either NaBH4 or a saturated NaHCO3 solution provided 12b-H or 12b-OH isoindolo[1,2-a]isoquinolinones, respectively.
Journal Title: RSC Advances
Year Published: 2022
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