The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In… Click to show full abstract
The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a Mycobacterium tuberculosis model.
Keywords:
effects mycobacterium;
generating enzyme;
formylglycine generating;
potential antibacterial;
activity;
antibacterial effects
Journal Title: RSC Advances
Year Published: 2022
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Journal Title: RSC Advances
Year Published: 2022
Link to full text (if available)
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recommendations!