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Norfloxacin and ofloxacin are two frequently prescribed second-generation fluoroquinolone antibiotics with an identical 4-quinolone chromophore and hence, are difficult to distinguish by conventional methods (UV or fluorescence). We have designed… Click to show full abstract
Norfloxacin and ofloxacin are two frequently prescribed second-generation fluoroquinolone antibiotics with an identical 4-quinolone chromophore and hence, are difficult to distinguish by conventional methods (UV or fluorescence). We have designed a Tb3+/Eu3+/cholate cocktail that enabled us to differentiate these two drugs and rapidly measure their concentrations when present together. Additionally, a Tb3+-cholate gel-based paper sensor was developed to detect and quantify them in a single drug containing system with a limit of detection (LOD) well below 100 nM.
Journal Title: RSC Advances
Year Published: 2022
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