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Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group

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The novel tris(4-azidophenyl)methanol, a multifunctionalisable aryl azide, is reported. The aryl azide can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild… Click to show full abstract

The novel tris(4-azidophenyl)methanol, a multifunctionalisable aryl azide, is reported. The aryl azide can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Moreover, the easily accessible aryl azide can be functionalised via copper-catalysed cycloaddition reactions, providing additional opportunities for materials chemistry applications.

Keywords: tris azidophenyl; protecting group; azidophenyl methanol; aryl azide

Journal Title: RSC Advances
Year Published: 2023

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