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Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams via DBU catalysis has been developed. The substrates were well-tolerated with high regio-… Click to show full abstract
Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams via DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The control experiments revealed that the hydrogen of the amide was the key factor.
Keywords:
highly regioselective;
lactams via;
ketones ketoamides;
cascade reaction;
unsaturated ketones
Journal Title: RSC Advances
Year Published: 2023
Link to full text (if available)
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Journal Title: RSC Advances
Year Published: 2023
Link to full text (if available)
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recommendations!