A mild, modular and efficient synthetic method with broad substrate scope was developed for aspulvinones. Nine natural aspulvinones were synthesized, six of which were for the first time. The aldol… Click to show full abstract
A mild, modular and efficient synthetic method with broad substrate scope was developed for aspulvinones. Nine natural aspulvinones were synthesized, six of which were for the first time. The aldol condensation delivered Z-configuration products predominantly in MeCN. Meanwhile, alkoxy exchange occurred in MeOH and EtOH. Aspulvinone O and E, and substrate 49, 50, and 51 exhibited modest anti-SARS-CoV-2 activity in a high-throughput screening and enzyme kinetics assay.
Keywords:
synthesis aspulvinone;
condensation;
collective synthesis;
aspulvinone analogues;
aldol condensation
Journal Title: RSC Advances
Year Published: 2023
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Journal Title: RSC Advances
Year Published: 2023
Link to full text (if available)
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recommendations!