We have described the first example of an umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition between two aryl aldehydes and a nitrile under the influence of TMSOTf… Click to show full abstract
We have described the first example of an umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition between two aryl aldehydes and a nitrile under the influence of TMSOTf that proceeds through the formation of N–C, O–C and C–C bonds providing a simple synthetic protocol for obtaining 2,4,5-trisubstituted oxazoles.
Keywords:
strategy intermolecular;
intermolecular cycloaddition;
trisubstituted oxazoles;
umpolung strategy;
aryl aldehydes
Journal Title: Chemical Science
Year Published: 2022
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Journal Title: Chemical Science
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!