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In the present study, norbornene-tetrazine ligation chemistry is harnessed for developing clickable RNA switches in biological contexts. This RNA control strategy is explored with a variety of applications. We further… Click to show full abstract
In the present study, norbornene-tetrazine ligation chemistry is harnessed for developing clickable RNA switches in biological contexts. This RNA control strategy is explored with a variety of applications. We further demonstrate the application of RNA-based norbornene-tetrazine ligation chemistry for controlling CRISPR systems. Moreover, the manipulation of gene editing in human cells is accomplished.
Keywords:
norbornene tetrazine;
chemistry;
rna;
tetrazine ligation;
ligation chemistry
Journal Title: Chemical Science
Year Published: 2022
Link to full text (if available)
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Journal Title: Chemical Science
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!