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Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function

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Plant homeodomain fingers (PHD-fingers) are a family of reader domains that can recruit epigenetic proteins to specific histone modification sites. Many PHD-fingers recognise methylated lysines on histone tails and play... Click to show full abstract

Plant homeodomain fingers (PHD-fingers) are a family of reader domains that can recruit epigenetic proteins to specific histone modification sites. Many PHD-fingers recognise methylated lysines on histone tails and play...

Keywords: target aromatic; cage phd; cyclic peptides; reader; peptides target; aromatic cage

Journal Title: Chemical Science
Year Published: 2023

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