Herein, we report an enantioselective cyanation of propargylic C-H bonds by combining photoredox catalysis with a copper-catalyzed radical relay in which the propargylic radical was generated by an intramolecular 1,5-HAT… Click to show full abstract
Herein, we report an enantioselective cyanation of propargylic C-H bonds by combining photoredox catalysis with a copper-catalyzed radical relay in which the propargylic radical was generated by an intramolecular 1,5-HAT process. This reaction provides easy access to optically pure propargyl nitrile compounds under mild conditions.
Keywords:
catalysis;
copper;
cyanation propargylic;
enantioselective cyanation;
propargylic bonds
Journal Title: Chemical communications
Year Published: 2023
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Journal Title: Chemical communications
Year Published: 2023
Link to full text (if available)
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recommendations!