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An efficient method for the synthesis of 1,4-ketoaldehydes via the cross-coupling of N-alkenoxyheteroarenium salts and primary aldehydes is developed. This method provides a broad substrate scope and excellent functional group… Click to show full abstract
An efficient method for the synthesis of 1,4-ketoaldehydes via the cross-coupling of N-alkenoxyheteroarenium salts and primary aldehydes is developed. This method provides a broad substrate scope and excellent functional group compatibility. The utility of this method is demonstrated via the diverse transformations of heterocyclic compounds and cycloheptanone, as well as the late-stage functionalization of biorelevant molecules.
Keywords:
selective intermolecular;
strategy chemically;
intermolecular cross;
cross;
umpolung strategy;
chemically selective
Journal Title: Chemical communications
Year Published: 2023
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Journal Title: Chemical communications
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!