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Creation of single molecular conjugates of metal-organic cages and DNA.

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Here we report the development of an equimolar conjugate of a metal-organic cage (MOC) and DNA (MOC-DNA). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a… Click to show full abstract

Here we report the development of an equimolar conjugate of a metal-organic cage (MOC) and DNA (MOC-DNA). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a template DNA having a complementary base sequence. Moreover, conjugation with the MOC drastically enhanced the permeability of DNA through the lipid bilayer, presenting great potential as a drug delivery system.

Keywords: creation single; molecular conjugates; metal organic; single molecular; moc dna; conjugates metal

Journal Title: Chemical communications
Year Published: 2023

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