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Tailoring the positive and negative solvatochromism for chalcone analogues to detect heterozygous protein co-aggregation.

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It is rare for one fluorophore scaffold to harbor both positive and negative solvatochromism. Herein, we tailor chalcone analogues to achieve both positive- and negative-polarity sensitivity of fluorescence intensity. We… Click to show full abstract

It is rare for one fluorophore scaffold to harbor both positive and negative solvatochromism. Herein, we tailor chalcone analogues to achieve both positive- and negative-polarity sensitivity of fluorescence intensity. We explore two chalcones of opposite solvatochromism to simultaneously detect the co-aggregation of wild-type and mutant superoxide dismutase that cause amyotrophic lateral sclerosis disease.

Keywords: aggregation; positive negative; solvatochromism; chalcone analogues; negative solvatochromism

Journal Title: Chemical communications
Year Published: 2023

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