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Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1

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Sofalcone (Sof), a synthetic analog of sophoradin, is a type of natural phenol derived from the traditional medicinal herb Sophora subprostrata, with potent anti-inflammatory activity. However, the mechanisms of action... Click to show full abstract

Sofalcone (Sof), a synthetic analog of sophoradin, is a type of natural phenol derived from the traditional medicinal herb Sophora subprostrata, with potent anti-inflammatory activity. However, the mechanisms of action...

Keywords: inhibits inflammatory; inflammatory response; response caco; chemoproteomics reveals; sofalcone inhibits; reveals sofalcone

Journal Title: Chemical Communications
Year Published: 2023

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