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Herein, we report the first microwave-assisted remote-C-H functionalization aided by a simple nitrile directing template. Notably, the present protocol showed a broad substrate scope VIA enabling meta-C-H arylation, acetoxylation, and… Click to show full abstract
Herein, we report the first microwave-assisted remote-C-H functionalization aided by a simple nitrile directing template. Notably, the present protocol showed a broad substrate scope VIA enabling meta-C-H arylation, acetoxylation, and cyanation. Significantly, the microwave-accelerated meta-C-H functionalization was effective with short reaction times without compromising yields and site selectivity. In addition, ibuprofen drug diversification was accomplished by carrying out arylation, acetoxylation, and cyanation. Importantly, meta-dual-hetero functionalization has been presented.
Journal Title: Chemical communications
Year Published: 2023
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