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Rh(III)-catalyzed regioselective versatile indole derivatization: delivering potential of rare β-(1H-indol-2-yl)-β-amino acids in one pot.

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Rh-catalyzed selective C-H functionalization of indoles with two routes was developed: an alkenylation-annulation with the addition of KHSO4 and alkenylation-elimination in the presence of CsOAc to the corresponding products, respectively.… Click to show full abstract

Rh-catalyzed selective C-H functionalization of indoles with two routes was developed: an alkenylation-annulation with the addition of KHSO4 and alkenylation-elimination in the presence of CsOAc to the corresponding products, respectively. Notably, one-pot hydrolysis and benzoylation of the annulation products successfully afforded easily separable β-(1H-indol-2-yl)-β-amino acid derivatives.

Keywords: indol amino; iii catalyzed; one pot

Journal Title: Chemical communications
Year Published: 2023

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