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Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers.

Herein we report the design and synthesis of a terphen[n]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs)… Click to show full abstract

Herein we report the design and synthesis of a terphen[n]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs) with high affinity, showing great potential as a NMBAs reversal agent in pharmaceutical research.

Keywords: soluble terphen; terphen arene; reversal agent; terphen; water soluble

Journal Title: Chemical communications
Year Published: 2023

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