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Target-switched artificial biochemical circuit for a versatile and sensitive colorimetric detection platform

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The presence of the target causes the structural switch of a metastable hairpin template probe (MH) for triggering a self-primed artificial biochemical circuit to produce numerous DNAzyme replicates, which in… Click to show full abstract

The presence of the target causes the structural switch of a metastable hairpin template probe (MH) for triggering a self-primed artificial biochemical circuit to produce numerous DNAzyme replicates, which in turn results in substantial signal amplification for highly sensitive colorimetric determination of nucleic acids.

Keywords: sensitive colorimetric; target switched; biochemical circuit; artificial biochemical

Journal Title: Chemical Communications
Year Published: 2023

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