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Chloroacetyl boronate N-tosylhydrazone as a versatile synthetic building block.

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Chloroacetyl boronate N-tosylhydrazone (CABT) has been synthesized as a reagent to generate a diverse range of molecular skeletons. CABT can undergo a series of transformations involving nucleophilic substitution of the… Click to show full abstract

Chloroacetyl boronate N-tosylhydrazone (CABT) has been synthesized as a reagent to generate a diverse range of molecular skeletons. CABT can undergo a series of transformations involving nucleophilic substitution of the chloride and coupling of the N-tosylhydrazones, followed by boryl group functionalization. We further demonstrated that this CABT reagent could enable a diversity-oriented synthesis.

Keywords: boronate tosylhydrazone; synthetic building; chloroacetyl boronate; tosylhydrazone versatile; versatile synthetic

Journal Title: Chemical communications
Year Published: 2023

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